Methyl group transfer from exogenous S-adenosylmethionine on to plasma-membrane phospholipids without cellular uptake in isolated hepatocytes
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چکیده
منابع مشابه
Metabolism of exogenous S-adenosylmethionine in isolated rat hepatocyte suspensions: methylation of plasma-membrane phospholipids without intracellular uptake.
Administration of S-adenosylmethionine (AdoMet), the main biological methyl donor, has been shown to exert favourable effects on liver disorders in man and animal models. The mechanism of action of AdoMet has, however, remained elusive, mainly owing to controversies with respect to its capacity to enter intact liver cells. Incubation of isolated rat hepatocytes with 2 or 50 microM -methyl-14C-A...
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The preparation, purification, and analysis of a variety of new sulfonium derivatives of methionine is reported. Deamination of S-adenosyl-L-methionine with nitrous acid yielded, depending on experimental conditions, S-adenosyl L-(Z-hydroxy-4-methylthio)butyric acid or S-inosyl-L-(Z-hydroxy 4 methylthio)butyric acid. S-Inosyl L methionine was obtained by enzymatic deamination of S-adenosyl-Lhom...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0264-6021
DOI: 10.1042/bj2060481